Innate and adaptive immunity in children with psychotic forms of autism-spectrum disorders
Kliushnik, T.P.; Androsova, L.V.; Simashkova, N.V.; Zozulia, S.A.; Otman, I.N.; Koval'-Zaĭtsev, A.A.
Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova 111(8 Part 1): 41-45
2011
ISSN/ISBN: 1997-7298 PMID: 21946139 Document Number: 13162
Leukocyte elastase (LE) activity, functional activity of alpha1-proteinase inhibitor, C-reactive protein, autoantibodies to nerve growth factor and to basic myelin protein have been studied in the blood serum of children with psychotic forms of autistic disorders - children psychosis (F84.02) and atypical children psychosis (F84.11). The activation of innate immunity (the increase in LE activity and acute phase proteins) was seen in children psychosis. The more severe mental disturbances, that are characteristic of endogenous atypical children psychosis, were accompanied by the activation of both innate and adaptive immunity ( the increase of the level of autoantibodies to neuroantigenes in the peripheral blood). Correlations between immunological and clinical parameters suggest the involvement of innate and adaptive immunity in the formation of autistic and cognitive disorders in children.
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