The enigma of sperm-egg recognition in mice
Dean, J.
Society of Reproduction and Fertility Suppl 63: 359-365
2007
ISSN/ISBN: 1747-3403 PMID: 17566284 Document Number: 606335
Mouse fertilization occurs in the oviduct where spermatozoa bind to the zona pellucida, penetrate the extracellular matrix and fuse with the egg's plasma membrane. Following fertilization, the zona pellucida, is modified to prevent sperm binding and penetration. The molecular basis of these interactions have long intrigued investigators, but remain incompletely understood. The recent use of mouse genetics has prompted review of current knowledge and suggests new models for the critical events for fertilization and early embryo development.