Effects of daidzein on sperm quality, testis gain and testosterone in mice
Han, Z.-Y.; Wang, G.-L.; Chen, W.; Zhang, L.-J.
Zhonghua Nan Ke Xue 9(8): 566-568
2003
ISSN/ISBN: 1009-3591 PMID: 14689883 Document Number: 556704
To evaluate the effects of daidzein on sperm quality of male mice. Three different doses of daidzein were supplemented to pubertal male mice for 21 days(5 mg/kg, 100 mg/kg, 1,000 mg/kg ration). The viability of sperm was determined by eosin-Y, the acrosome was observed by Wright-Giemsa staining, and the testosterone was measured by radioimmunoassay. Daidzein at the dose of 5 mg/kg ration significantly increased serum testosterone levels (P < 0.01), prompted testis gain (P < 0.05), and improved spermatozoa quality. Daidzein at dose of 1,000 mg/kg ration could inhibit the secretion of serum testosterone (P < 0.01), without significant variation in spermatozoa quality. Daidzein at dose of 100 mg/kg ration did not significantly affect sperm quality and other index. Daidzein can affect sperm quality and in dosage-dependant ways.