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Effect of apolipoprotein A-1 containing steroid hormones on DNA and protein biosynthesis in cells of ascitic hepatoma HA-1

Panin, L.E.; Khoshchenko, O.M.; Poliakov, L.M.

Voprosy Onkologii 53(5): 562-565

2007

ISSN/ISBN: 0507-3758
PMID: 18154121
Document Number: 605611
The rate of DNA and protein biosynthesis in murine hepatoma HA-1 was accelerated when steroid hormones, containing a reduced delta4,3-keto group in the A-ring, were used in combination with apolipoprotein A-1. That was demonstrated for apolipoprotein A-1 complexes with dehydroepiandrosterone, dehydroepiandrosterone sulfate and tetrahydrocortisol. Apolipoprotein A-1 complexes serve as a vehicle for steroids penetration into cells to influence protein biosynthesis.

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