Chemical constituents in root of Zanthoxylum nitidum
Hu, J.; Zhang, W.-D.; Liu, R.-H.; Zhang, C.; Shen, Y.-H.; Xu, X.-K.; Liang, M.-J.; Li, H.-L.
Zhongguo Zhong Yao Za Zhi 31(20): 1689-1691
2006
ISSN/ISBN: 1001-5302 PMID: 17225536 Document Number: 605158
To study the chemical constituents of Zanthoxylum nitidum. Column chromatography on Silica gel and Sephadex LH - 20, and recrystallization were applied for the isolation and purification of the constituents. The structures were elucidated on the basis of spectral analysis, chemical evidences and by comparison with the data reported in literature. From the CHCl3 fraction and n-butanol fraction of the EtOH extract of the roots of Z. nitidum, 10 compounds were isolated and identified as 2, 4-dihydroxypyrimidine (1), syringic acid (2) , 2, 6-dimethoxy-1, 4-benzoquinone (3) , 4-hydroxybenzoic acid (4), ethylparaben (5), (Z)-3-(2, 3, 4-trimethoxyphenyl) acrylic acid (6), 5, 6, 7-trimethoxycoumarin (7), stigmast-9 (11) -en-3-ol (8), daucosterol (9), beta-sitosterol (10). Compounds 1-9 were isolated and identified from the roots of Z. nitidum for the first time. Furthermore, we note here the first isolation of compound 6 as a natural product.