Effect of epsilon-aminocaproylamino acids on fibrin formation
Bruzgo, I.; Midura-Nowaczek, K.; Bruzgo, M.; Kaczyńska, J.; Roszkowska-Jakimiec, W.ła.
Acta Poloniae Pharmaceutica 63(2): 149-152
2006
ISSN/ISBN: 0001-6837 PMID: 17514879 Document Number: 603740
Effect of three epsilon-aminocaproylamino acids with significant antifibrinolytic activity on polymerization of fibrin monomer, clot retraction, fibrin structure, prothrombin consumption and thrombin activity was examined. epsilon-Aminocaproyl-L-norleucine and epsilon-aminocaproyl-L-leucine were weak inhibitors of thrombin activity and epsilon-aminocaproyl-L-norleucine slightly inhibited polymerization of fibrin monomers.