Generation of oxygen radicals and formation of fibrin thrombi in glomerular capillaries of rats with nephrotoxic nephritis
Ito, S.; Sugisaki, T.; Soezima, K.
Nihon Jinzo Gakkai Shi 31(2): 171-177
1989
ISSN/ISBN: 0385-2385 PMID: 2739116 Document Number: 340445
This paper describes the results of experiments designed to investigate the role of oxygen radicals in the pathogenesis of rat experimental glomerulonephritis. Generation of oxygen radicals was induced by phorbol ester in rats with Masugi nephritis, aminonucleoside nephrosis and streptozotocin-induced diabetes mellitus. Marked formation of fibrin thrombi was observed in the glomerular capillaries during the heterologous phase of Masugi nephritis, but not during the autologous phase. Induction of fibrin thrombi was also seen in nephrotic rats which had received the aminonucleoside, puromycin, but not in diabetic rats. These results suggest that in Masugi nephritis, oxygen radicals may be related to the formation of fibrin thrombi. Neutrophils seem to be of importance in the pathogenesis of such lesions.