Top Abstract Purchase Related
Home
>
Node
>
Subnode

Gamma globulin inhibition of fibrin clot formation

Davey, F.R.; Gordon, G.B.; Boral, L.I.; Gottlieb, A.J.

Annals of Clinical and Laboratory Science 6(1): 72-77

1976

ISSN/ISBN: 0091-7370
PMID: 1247286
Document Number: 100064
Myeloma gamma globulins have been reported to interfere with fibrinogen-fibrin conversion. A patient with multiple myeloma is described with a gamma globulin IgG1lambda concentration of 11 g per dl, prolonged thrombin time and poor clot retraction. Purified gamma globulin from the patient's serum and from normal serum caused prolongation of the thrombin time and reptilase clotting time assays in both normal plasma and in solutions of bovine fibrinogen. In addition, fibrin clots formed during the thrombin time assays were found to be ultrastructurally abnormal. This data suggests that the interaction of gamma globulin in the polymerization of fibrin may, in at least some cases, be due to nonspecific protein interaction.

Document emailed within 1 workday
Secure & encrypted payments

Ishmukhametova, D.N.; Mozhina, A.A. 1984: Relation of the formation of the fibrin network of a blood clot to the amount of thrombin in complexes with endogenous heparin Anesteziologiia i Reanimatologiia 2: 30-34
Aoki, N. 1993: Clot retraction increases clot resistance to fibrinolysis by condensing alpha 2-plasmin inhibitor crosslinked to fibrin Thrombosis and Haemostasis 70(2): 376
Hanaoka, M.; Nomoto, K.; Waksman, B.H. 1970: Appendix and gamma M-antibody formation. I. Immune response and tolerance to bovine gamma globulin in irradiated, appendix-shielded rabbits Journal of Immunology 104(3): 616-625
Hanaoka, M.; Williams, R.M.; Waksman, B.H. 1971: Appendix and gamma M antibody formation. 3. Uptake and distribution of soluble or alum-precipitated bovine gamma-globulin injected into the rabbit appendix Laboratory Investigation; a Journal of Technical Methods and Pathology 24(1): 31-37
Barandun, S.; Skvaril, F.; Morell, A. 1976: Prophylaxis and therapy with gamma globulin. General characterization and clinical use of gamma globulin preparations Schweizerische Medizinische Wochenschrift 106(16): 533-542
Platonova, T.N.; Musialkovskaia, A.A.; Tolstykh, V.M.; Belitser, V.A. 1980: Inhibition of fibrin assembly by fragment D and its dimer derived from fibrinogen and stabilized fibrin. Evidence for the two-step type of inhibition Biokhimiia 45(10): 1780-1787
Rustamova, B.A.; Molchanova, L.V.; Kudriashov, B.A. 1970: The effect of heparin on fibrin clot stabilization Voprosy Meditsinskoi Khimii 16(3): 290-293
Mirshahi, M.; Azzarone, B.; Soria, J.; Mirshahi, F.; Soria, C. 1991: The role of fibroblasts in organization and degradation of a fibrin clot Journal of Laboratory and Clinical Medicine 117(4): 274-281
Sumi, H.; Takasugi, S. 1978: Effect of fibrin clot on plasma enzyme activation Nihon Seirigaku Zasshi. Journal of the Physiological Society of Japan 40(3): 59-61
Nicosia, R.F.; Tchao, R.; Leighton, J. 1983: Angiogenesis-dependent tumor spread in reinforced fibrin clot culture Cancer Research 43(5): 2159-2166
Bednaăík, T.; Cajthamlová, H. 1976: Suppression of humoral antibody formation in rabbits. Administration of alpha globulin fraction of human plasma and antilymphocytic globulin Casopis Lekaru Ceskych 115(48): 1490-1492
Andrew, M.; Brooker, L.; Leaker, M.; Paes, B.; Weitz, J. 1992: Fibrin clot lysis by thrombolytic agents is impaired in newborns due to a low plasminogen concentration Thrombosis and Haemostasis 68(3): 325-330
Dolesobel, W. 1972: Use of new methods for studies of blood coagulation. II. Clot-sedimentation-technic for the determination of antithrombin i effect of fibrin Wiener Medizinische Wochenschrift 122(41): 585-590
Fingert, H.J.; Chen, Z.; Mizrahi, N.; Gajewski, W.H.; Bamberg, M.P.; Kradin, R.L. 1987: Rapid growth of human cancer cells in a mouse model with fibrin clot subrenal capsule assay Cancer Research 47(14): 3824-3829
Mikhalev, V.V. 1971: Blood coagulation and the physico-chemical properties of the fibrin-thrombocytic structure of the clot in patients with post-infarct cardiosclerosis Terapevticheskii Arkhiv 43(8): 99-102
Takahashi, M.; Oshimi, K.; Mizoguchi, H. 1990: Inhibition of human granulocyte-macrophage colony formation by interleukin 2-treated lymphocytes is mediated by interferon gamma and tumor necrosis factor alpha Experimental Hematology 18(5): 395-399
Itoh, J.; Nakagawa, H.; Sasaki, H.; Takahashi, T. 1985: A fibrin clot containing of anticancer drug for intra-arterial chemo-embolization therapy. (2) Chemotherapeutic effects on a model hepatoma using VX-2 carcinoma in rabbits Gan to Kagaku Ryoho. Cancer and ChemoTherapy 12(2): 258-264
Kurokawa, T.; Iwasa, S.; Kakinuma, A.; Stassen, J.M.; Lijnen, H.R.; Collen, D. 1991: Enhancement of clot lysis in vitro and in vivo with a bispecific monoclonal antibody directed against human fibrin and against urokinase-type plasminogen activator Thrombosis and Haemostasis 66(6): 684-693
Colle, J.P.; Mishal, Z.; Lesty, C.; Mirshahi, M.; Peyne, J.; Baumelou, A.; Bensman, A.; Soria, J.; Soria, C. 1999: Abnormal fibrin clot architecture in nephrotic patients is related to hypofibrinolysis: influence of plasma biochemical modifications: a possible mechanism for the high thrombotic tendency? Thrombosis and Haemostasis 82(5): 1482-1489
Gerrah, R.; David, O. 2013: In vivo quantification of clot formation in extracorporeal circuits Studies in Health Technology and Informatics 184: 148-150