Diagnosis and treatment of pure red-cell aplasia induced by erythropoiesis stimulating agents
Rossert, J.ér.ôm.; Casadevall, N.
Nephrologie and Therapeutique 2(Suppl 4): S283-S286
2006
ISSN/ISBN: 1769-7255 PMID: 17373271 Document Number: 602078
Pure red-cell aplasia is an isolated disorder of erythropoiesis that leads to the pment of severe, isolated anemia. In chronic kidney disease patients treated with n erythropoiesis stimulating agent (ESA), development of anti-erythropoietin antibodies s one of the leading causes of pure red-cell aplasia. It requires to stop treatment with ESA, but in the vast majority of cases immunosuppressive therapy is necessary to induce the disappearance of anti-erythropoietin antibodies. Isolated case reports suggest that, at least in some patients, treatments with ESA can be resumed after recovery from antibody-mediated pure red-cell aplasia.