Antibody-mediated suppression of erythropoiesis in dogs with red blood cell aplasia
Weiss, D.J.
American Journal of Veterinary Research 47(12): 2646-2648
1986
ISSN/ISBN: 0002-9645 PMID: 3099614 Document Number: 268689
Eight dogs with acquired RBC aplasia were studied. Unfractionated sera and serum immunoglobulin G fractions were examined for the presence of erythroid progenitor cell inhibitors. A serum immunoglobulin G inhibitor directed against precursors of erythroid colony-forming units was detected in 3 of 5 dogs that were direct Coombs' test-negative and in 1 of 3 dogs that were direct Coombs' test-positive. Sera from these dogs were treated with binary ethyleneimine to inactivate any viruses present. The inhibitory effects of the treated serum on erythroid colony-forming units was not ameliorated.