Singlet oxygen in photosensitization
Moan, J.; Juzenas, P.
Journal of Environmental Pathology Toxicology and Oncology Official Organ of the International Society for Environmental Toxicology and Cancer 25(1-2): 29-50
2006
ISSN/ISBN: 0731-8898 PMID: 16566709 Document Number: 598580
Oxygen is a ubiquitous element and a vitally important substance for life on the Earth, and especially for human life. Living organisms need oxygen for most, if not all, of their cellular functions. On the other hand, oxygen can produce metabolites that are toxic and potentially lethal to the same cells. Being reactive and chemically unstable reactive oxygen species (ROS) are the most important metabolites that initiate reduction and oxidation (redox) reactions under physiological conditions. Oxygen in its excited singlet state (O-1(2)) is probably the most important intermediate in such reactions. Since the discovery of oxygen by Joseph Priestley in 1775 it has been recognized that oxygen can be both beneficial and harmful to life.