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Photosensitized formation of singlet oxygen in water solutions of covalent porphyrin-antibody conjugates

Egorov, S.I.; Krasnovskiĭ, A.A.; Pankovskiĭ, D.B.; Ponomarev, G.V.; Savitskiĭ, A.P.

Biulleten' Eksperimental'noi Biologii i Meditsiny 109(4): 349-351

1990

ISSN/ISBN: 0365-9615
PMID: 2386825
Document Number: 362851
The effective photogeneration of singlet molecular oxygen (1O2) by porphyrins (coproporphyrin I; 2,4-bi (alpha-methoxyethyl) deuteroporphyrin IX and cyclopanten-coproporphyrin I) conjugated with antibodies (mouse monoclonal IgG and IgM and human gamma-globulin) have been observed with the direct luminescence method of 1O2 detection. Absolute quantum yields of 1O2 formation by the conjugates have been determined. The data suggest that porphyrin-antibody conjugates are promising for the use as drugs in photodynamic tumor treatment.

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