Top Abstract Purchase Related
Home
>
Node
>
Subnode

Alteration of insulin secretion in the elderly

Aizawa, T.

Nihon Rinsho. Japanese Journal of Clinical Medicine 64(1): 34-38

2006

ISSN/ISBN: 0047-1852
PMID: 16408444
Document Number: 598579
Aging per se is associated with reduced insulin secretion, which is an important contributing factor for pandemic of diabetes worldwide. Although underlying mechanism for it is not fully elucidated, a combination of reduced beta cell mass and impairment of insulin granule handing in the cell is most likely which may be due to age-related mitochondrial dysfunction and/or dysregulation of transcriptional factors. For effective prevention of diabetes in the elderly population, restoration of beta cell function is desired. Meanwhile, identification of insulin-deficient elderly patients with diabetes and an earlier institution of insulin therapy for them are recommended for improvement of treatment outcome.

Document emailed within 1 workday
Secure & encrypted payments

Joel, W.; Vogel, B.; Schmülling, R.M.; Keller, E.; Eggstein, M. 1975: Alteration of insulin secretion during isocaloric reduction diet rich on carbohydrates, resp. fat, in weight loss of adipose patients Münchener Medizinische Wochenschrift 117(20): 844
Zilker, T.; Ermler, R.; Paterek, K.; Bottermann, P. 1977: C-peptide secretion dependent on serum glucose and insulin secretion - autoregulation of insulin secretion Verhandlungen der Deutschen Gesellschaft für Innere Medizin 83: 1385-1388
Petralito, A.; Lunetta, M.; Fiore, C.E.; Liuzzo, A.; Giuga, G. 1978: Influence of verapamil on blood sugar and insulin secretion after intravenous administration of glucose and on somatotropin secretion after insulin stimulation Bollettino Della Societa Italiana di Cardiologia 23(2): 404-411
Carducci Artenisio, A.; Albanese, M.C.; Allegra, V.; Ragonese, F.; Corsi, V. 1973: The autonomic nervous system and insulin secretion. IV. Inhibiting action of propranolol on insulin secretion after intravenous glucagon overload Bollettino della Societa Italiana di Biologia Sperimentale 49(14): 889-895
Carducci Artenisio, A.; Albanese, M.C.; Allegra, V.; Alibrando, S.; Sprovieri, M.; Caruso, A.; Corsi, V. 1972: Autonomic nervous system and secretion of insulin. II. Effect of adrenergic blockaders on the insulin secretion in response to tolbutamide Folia Endocrinologica 25(6): 467-485
Yamada, S.; Kojima, I. 2005: Insulin secretion in pancreatic beta cells: role of protein palmitoylation in glucose-induced insulin secretion Seikagaku. Journal of Japanese Biochemical Society 77(6): 505-510
Sener, A.; Owen, A.; Malaisse-Lagae, F.; Malaisse, W.J. 1989: Stimulus-secretion coupling of arginine-induced insulin release. Effect of 2-aminoisobutyric acid upon ornithine decarboxylase activity and insulin secretion Research Communications in Chemical Pathology and Pharmacology 65(1): 65-80
Haslbeck, M. 1974: Insulin secretion after glucose loading. Studies on insulin secretion in healthy and diabetic subjects after administration of glucose Fortschritte der Medizin 92(32): 1317-1318
Chang, T.C.; Wang, L.M.; Cheng, C.Y.; Kuo, H.F.; Liu, P.C.; Ho, L.T. 1990: The action of gliclazide on insulin secretion and insulin sensitivity in non-obese non-insulin dependent diabetic patients Zhonghua Yi Xue Za Zhi 46(2): 79-85
Beck-Nielsen, H.; Henriksen, J.E.; Alford, F.; Hother-Nielson, O. 1996: In vivo glucose metabolism, insulin secretion and, insulin action in Europids with non-insulin-dependent diabetes mellitus (NIDDM) and their first-degree relatives Diabetic Medicine: a Journal of the British Diabetic Association 13(9 Suppl 6: S78-S84
Pasquali, R.; Pelusi, C.; Ragazzini, C.; Hasanaj, R.; Gambineri, A. 2002: Glucose tolerance, insulin secretion and insulin sensitivity in polycystic ovary syndrome Jop: Journal of the Pancreas 3(1): 1-7
Deckert, T. 1980: The influence of supervision and endogenous insulin secretion on the course of insulin-dependent diabetes mellitus Acta Endocrinologica. Supplementum 238: 31-38
Johansen, K. 1973: A new principle for the comparison of insulin secretory responses. I. The effect of age on insulin secretion Acta Endocrinologica 74(3): 511-523
Tang, X.-f.; Li, H.; Wang, J.-g.; Chu, S.-l.; Guo, J.-z.; Zhu, D.-l. 2004: Insulin secretion and insulin sensitivity in 1193 inpatients with essential hypertension Zhonghua Nei Ke Za Zhi 43(10): 735-739
Vague, P. 1982: Respective roles of insulin resistance and disorders of secretion of this hormone in the non-insulin-dependent diabetic Journees Annuelles de Diabetologie de l'Hotel-Dieu 1982: 7-17
Kneteman, N.M.; Marchetti, P.; Tordjman, K.; Bier, D.M.; Santiago, J.V.; Swanson, C.J.; Olack, B.J.; Scharp, D.W. 1992: Effects of cyclosporine on insulin secretion and insulin sensitivity in dogs with intrasplenic islet autotransplants Surgery 111(4): 430-437
Roubsanthisuk, W.; Watanakejorn, P.; Tunlakit, M.; Sriussadaporn, S. 2006: Hyperthyroidism induces glucose intolerance by lowering both insulin secretion and peripheral insulin sensitivity Journal of the Medical Association of Thailand 89(Suppl 5): S133-S140
Groop, L. 2000: Pathogenesis of type 2 diabetes: the relative contribution of insulin resistance and impaired insulin secretion International Journal of Clinical Practice. Suppl 113: 3-13
Czyźyk, A.; Lawecki, J.; Strycek-Kaminska, D. 1981: Cholinergic regulation of insulin and glucagon secretion in healthy people and in patients with non-insulin dependent diabetes Zeitschrift für die Gesamte Innere Medizin und ihre Grenzgebiete 36(2): 43-47
Pelikánová, T.; Kohout, M.; Válek, J.; Kazdová, L.; Karasová, L.; Base, J.; Stefka, Z. 1990: Insulin secretion and insulin resistance in type Ii diabetes. Relation to fatty acid composition of serum phospholipids Casopis Lekaru Ceskych 129(51): 1605-1610