Cryptococcal meningo-encephalitis in an apparently immunocompetent patient
Bretaudeau, K.; Eloy, O.; Richer, A.; Bruneel, F.; Scott-Algara, D.; Lortholary, O.; Pico, F.
Revue Neurologique (Paris) 162(2): 233-237
2006
ISSN/ISBN: 0035-3787 PMID: 16518265 Document Number: 598343
Introduction. Cryptococcal meningo-encephalitis is a rare disease occurring more frequently in immunocompromised hosts. Case report. We report the case of an apparently immunocompetent patient who developed a recurrent neurological deficit with lymphocytic meningitis. The time from the first symptoms to diagnosis was 8 months. We noted mild CD4+ lymphocytopenia (500 cells/mm(3)) without HIV infection, CD4+ lymphocytes were not reactive for a panel of antigens. Conclusion. This case illustrates the usefulness of cerebrospinal fluid Cryptococcus Neoformans antigen test in patients with an unexplained neurological syndrome with a lymphocytic meningitis together with quantification of circulating lymphocytes clusters and analyse of their function in opportunistic infections.