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Isolation of viruses in the cerebrospinal fluid in a case of acute varicella meningo-encephalitis

Auzanneau, G.; Chagnon, A.; Morillon, M.; Verdier, M.; de Jaureguiberry, J.P.

Presse Medicale 16(28): 1363-1364

1987

ISSN/ISBN: 0755-4982
PMID: 2819843
Document Number: 293010
The authors report a case of severe, life-threatening, meningo-encephalitis occurring in a young nonimmunodepressed adult with varicella. The demonstration of a cytopathogenetic effect of his cerebrospinal fluid and of immunoglobulins M specific to the varicella-zoster virus was in favour of an acute, directly viral-dependent encephalitis rather than an immune-mediated leucoencephalitis, as used to be commonly admitted. This is an incitement to use acyclovir in such cases, the effect of which contributes to reinforce this pathogenic hypothesis.

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