Aotus nancymaae as a potential model for the testing of anti-sporozoite and liver stage vaccines against Plasmodium falciparum
Collins, W.E.; Sullivan, J.S.; Williams, A.; Nace, D.; Williams, T.; Galland, G.Gale.; Barnwell, J.W.
American Journal of Tropical Medicine and Hygiene 74(3): 422-424
2006
ISSN/ISBN: 0002-9637 PMID: 16525100 Document Number: 598117
The Santa Lucia strain of Plasmodium falciparum was transmitted to Aotus lemurinus griseimembra, A. azarae boliviensis, A. vociferans, and A. nancymaae monkeys by bite and by intravenous inoculation of sporozoites dissected from Anopheles freeborni, An. stephensi, An. gambiae, An. albimanus, and An. maculatus mosquitoes. The data obtained from these infections indicate that A. nancymaae can be considered a suitable host model when combined with falciparum for the testing of candidate anti-sporozoite and liver stage vaccines. the Santa Lucia strain of falciparum for the testing of candidate anti-sporozoite and liver stage vaccines.