Genomic and extragenomic mechanisms of antiglucocorticoid action of gestagens on thymocytes
Semeĭkin, A.V.; Dukhanin, A.S.; Samoĭlikov, R.V.; Rzheznikov, V.M.; Shimanovskiĭ, N.L.
Eksperimental'naia i Klinicheskaia Farmakologiia 69(4): 43-46
2006
ISSN/ISBN: 0869-2092 PMID: 16995438 Document Number: 598012
Effects of a new synthetic progesterone derivative 17a-acetoxy-3b-butanoyloxy-6-methyl-pregna-4,6-dien-20-one (ABMP) and the reference gestagen preparations on the rat thymus were evaluated by the degree of variation of the intracellular levels of calcium and cAMP, 3H-uridine inclusion into RNA, thymocyte viability, and thymus mass. It is shown that gestagens can produce antiglucocorticoid action on thymocytes, this activity being most pronounced in the case of ABMP.