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The experimental study of peculiarities and mechanism of neuroprotective action of mexidol in hemorrhagic stroke

Kraĭneva, V.A.

Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova Suppl 17: 71-76

2006

ISSN/ISBN: 1997-7298
PMID: 18193582
Document Number: 597114
An efficacy of mexidol, a Russian drug of the new generation, used in 100 mkg during 7 days has been demonstrated in rats in the model of experimentally caused intracerebral posttraumatic hematoma (hemorrhagic stroke). The drug significantly reduced the number of neurological impairments (paresis, riding-arena movements) and increased the animal's survival rate. Mexidol improved learning and memory in rats with hemorrhagic stroke in the passive avoidance test and exerted influence on the locomotor activity in the open field test.

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