Hyperresponsiveness of congestive nasal reflexes in allergic rhinitis
Sheahan, P.; Walsh, R.McConn.; Walsh, M.A.; Costello, R.W.
Rhinology 44(1): 68-73
2006
ISSN/ISBN: 0300-0729 PMID: 16550954 Document Number: 596022
Background. Nasal secretory hyperresponsiveness is well documented in allergic rhinitis, and is mediated in part by neural mechanisms. In contrast, reflex-mediated congestion is poorly documented in both normal and allergic subjects.Objective: To characterize congestive responses to unilateral nasal bradykinin challenge in normal and allergic subjects, and to investigate whether congestive hyperresponsiveness is present in allergic rhinitis.Methods: Normal subjects (n=13), and subjects with out-of-season seasonal allergic rhinitis (SAR) (n=16) underwent a unilateral nasal challenge protocol using filter paper disks, using Hartman's solution and bradykinin as challenge substances. Congestive responses were measured using acoustic rhinometry.Results: Normal subjects demonstrated a transient ipsilateral congestive response, and a circumscribed contralateral congestive response away from the major flow limiting section. Subjects with SAR demonstrated a more persistent ipsilateral congestive response, and a more pronounced, generalized contralateral congestive response affecting all areas of the contralateral nasal cavity. Significant differences were present between normal and SAR subjects.Conclusion: Congestive reflexes are present in normal and allergic subjects. Congestive hyperresponsiveness is present in allergic rhinitis.