Associations of hemostasis factors genes with early development of ischemic heart disease and manifestation of myocardial infarction in young age
Dankovtseva, E.N.; Zateĭshchikov, D.A.; Chudakova, D.A.; Koroleva, O.S.; Brovkin, A.N.; Nosikov, V.V.; Gaĭdukova, N.V.; Tishchenko, V.A.; Sidorenko, B.A.
Kardiologiia 45(12): 17-24
2005
ISSN/ISBN: 0022-9040 PMID: 16353042 Document Number: 586832
To study polymorphisms of genes of factors of the system of hemostasis in young patients with ischemic heart disease (IHD). Two groups of patients participated in the study: patients with first manifestation of IHD at the age < or = 50 years (men) or < or = 55 years (women) (n=158), and patients with first IHD manifestation at the age > or = 70 years (n=92). We studied polymorphic markers of genes encoding clotting factors V (F5) and VII (F7), subunit IIIa of platelet integrin (ITGB3), beta-chain of fibrinogen (FGB) and tissue plasminogen activator type 1 (PLANH1). After separation of a subgroup of patients with MI without preceding angina we revealed significant differences in distribution of frequencies of genotypes of polymorphic marker C(-426)T of factor V gene: genotype TT was significantly more frequent in young (14.9%) than in old (2%) patients (p=0.008). Multifactorial logistic regression revealed independent association of early IHD with smoking (OR 6.112 [2.567-14.552]; p<0.001) and presence of genotype TT of C(-426)T polymorphic marker of F5 gene (OR=9.410 [1.074-82.459]; p=0.043). Thus we obtained data on the presence of independent association between IHD risk and manifestation of MI in young age with genotype TT of polymorphic marker C(-426)T of F5 gene as well as with traditional risk factors of IHD.