The effect of prophylactic nicorandil infusion to reduce intraoperative myocardial ischemia during abdominal surgery in patients with risk factors of ischemic heart disease
Kaneko, T.; Hayashida, M.; Saito, Y.; Hikawa, Y.; Yasuda, K.
Masui. Japanese Journal of Anesthesiology 49(1): 54-59
2000
ISSN/ISBN: 0021-4892 PMID: 10689845 Document Number: 521976
Three hundred patients who had undergone abdominal surgery with risk factors of ischemic heart disease (IHD), such as hypertension, diabetes mellitus, hyperlipidemia, smoking, advanced age, obesity, familial history, electrocardiographic abnormality, other perivascular disease, and male, were included in this study. Patients older than forty years were included in the study. They were divided into two groups for a randomized double blind trial: nicorandil was administered in one group (group N) and placebo in another (group C), and we investigated the effect of prophylactic nicorandil infusion to reduce intraoperative myocardial ischemia. ST segment in leads II and Vs was recorded by ST trend monitor from the time of patient's entering the operating room to the time to exit. Intraoperative myocardial ischemia occurred in 11 patients in group N and in 32 patients in group C (P < 0.0001). Prophylactic nicorandil infusion was effective to reduce intraoperative myocardial ischemia in patients with risk factors of IHD during abdominal surgery.