Changes in the platelet-vascular system of hemostasis in patients with ischemic heart disease and hypertension after the treatment
Zadionchenko, V.S.; Kamenker, E.S.; Chikvashvili, I.A.
Kardiologiia 29(10): 51-54
1989
ISSN/ISBN: 0022-9040 PMID: 2575682 Document Number: 333558
The status of platelet aggregability, cyclic nucleotides and the thromboxane-prostacyclin system was examined in 40 patients with Functional Class II-III angina pectoris treated with perdipine, a calcium antagonist, and in 40 patients with Stage II hypertensive disease treated with tenolol, a beta-adrenoblocker. The therapy was found to modify the initially abnormal parameters of platelet-vessel hemostasis both in coronary heart disease and hypertension. When the initial parameters of platelet functional activity were normal, the treatment with perdipine and tenolol caused no noticeable changes.