Therapy of metastatic prostatic cancer by orchiectomy plus Anandron versus orchiectomy plus placebo. Initial results of a randomized multicenter study
Knönagel, H.; Bolle, J.F.; Hering, F.; Senn, E.; Hodel, T.; Neuenschwander, H.; Biedermann, C.
Helvetica Chirurgica Acta 56(3): 343-345
1989
ISSN/ISBN: 0018-0181 PMID: 2681086 Document Number: 333559
In the course of a randomized double blind trial conducted by 7 Swiss urological centres, 51 patients with advanced, not pretreated carcinoma of the prostate were included. Following orchiectomy the patients were either administered 300 mg Anandron daily (Roussel RU 23908) or Placebo. Twelve months later the Anandron-group shows a slightly better objective response whereas there is no difference in survival rates. The adverse effects of Anandron-treatment are described.