Initial treatment of cryptococcal meningitis in AIDS
Chotmongkol, V.; Arayawichanont, A.; Sawanyawisuth, K.; Thavornpitak, Y.
Southeast Asian Journal of Tropical Medicine and Public Health 36(1): 170-173
2005
ISSN/ISBN: 0125-1562 PMID: 15906662 Document Number: 585532
The comparison of initial treatment with amphotericin B (0.7 mg/kg/d) plus rifampin (600 mg/d) with amphotericin B (0.7 mg/kg/d) alone for 2 weeks, both followed by fluconazole (400 mg/d) for 8 weeks in the acute treatment of cryptococcal meningitis in AIDS by an open-randomized, controlled, prospective clinical trial is reported. Twenty patients were enrolled in each group. There were no significant differences between the groups in regard to a negative CSF culture for Cryptococcus neoformans in the 2(nd) and 10(th) weeks of treatment, time until normal body temperature after treatment, number of patients who died, and persistence of high CSF pressure after completion of treatment. Elevated intracranial pressure was an important factor associated with the patients who died. These results indicate that the combination of amphotericin B plus rifampin is not superior to amphotericin B alone.