Top Abstract Purchase Related
Home
>
Node
>
Subnode

Pharmacokinetics of fluconazole in serum and cerebrospinal fluid in a patient with AIDS and cryptococcal meningitis

Chin, T.; Fong, I.W.; Vandenbroucke, A.

PharmacoTherapy 10(4): 305-307

1990

ISSN/ISBN: 0277-0008
PMID: 2388877
Document Number: 348616
The detailed pharmacokinetics of fluconazole in serum and cerebrospinal fluid (CSF) were studied in a 37-yr-old man with AIDS and Cryptococcus neoformans meningitis, after an intravenous dose of 400 mg. Fluconazole exhibited a serum elimination half-life of 34.2 h, distribution volume of 0.56 litre/kg and clearance of 0.19 ml/min per kg. Peak CSF concn occurred at 4 h after the dose. Overall penetration of fluconazole based on the ratio of areas under the curve of CSF to serum was 70%. It is concluded that fluconazole exhibits an excellent pharmacokinetic profile for treatment of central nervous system fungal infections.

Document emailed within 1 workday
Secure & encrypted payments

Szafrańska, M. 1982: Changes in the levels of immunoglobulins G, A and M in the cerebrospinal fluid and serum of children with cerebrospinal meningitis. I. Serous cerebrospinal meningitis Pediatria Polska 57(5-6): 365-369
Jaruratanasirikul, S. 1996: Amphotericin B with or without flucytosine followed by fluconazole as primary therapy for cryptococcal meningitis in patients with AIDS Southeast Asian Journal of Tropical Medicine and Public Health 27(4): 719-723
Mootsikapun, P.; Chetchotisakd, P.; Anunnatsiri, S.; Choksawadphinyo, K. 2003: The efficacy of fluconazole 600 mg/day versus itraconazole 600 mg/day as consolidation therapy of cryptococcal meningitis in AIDS patients Journal of the Medical Association of Thailand 86(4): 293-298
Gudesblatt, M.; Gerber, O.; Vaillancourt, P.D.; Bronster, D. 1987: Quasi-normal cerebrospinal fluid in patients with acquired immunodeficiency syndrome and cryptococcal meningitis Revue Neurologique (Paris) 143(4): 290-293
Tansuphaswadikul, S.; Maek-a-Nantawat, W.; Phonrat, B.; Boonpokbn, L.; Mctm, A.Getahun.; Pitisuttithum, P. 2006: Comparison of one week with two week regimens of amphotericin B both followed by fluconazole in the treatment of cryptococcal meningitis among AIDS patients Journal of the Medical Association of Thailand 89(10): 1677-1685
Momoff, N.; Parrish, A. 2003: Fluconazole-resistant cryptococcal meningitis South African Medical Journal 93(6): 444
Scherber, A.; Henker, J. 1982: Chemotherapy of purulent meningitis in childhood. I. Pharmacokinetics of antibacterial drugs in the cerebrospinal fluid Kinderarztliche Praxis 50(4): 182-186
Okura, K.; Haruta, T.; Kobayashi, Y. 1984: Pharmacokinetics in the cerebrospinal fluid after simultaneous administration of latamoxef and ampicillin to rabbits with staphylococcal meningitis Japanese Journal of Antibiotics 37(9): 1637-1646
Collett, G.; Parrish, A. 2007: Fluconazole donation and outcomes assessment in cryptococcal meningitis South African Medical Journal 97(3): 175-176
Karlsson, M.; Lidman, K.; Philipson, A.; Berglund, O.; Carlsson, B.; Karlsson, A. 1986: The first case of cryptococcal meningitis in a Swedish patient with AIDS Lakartidningen 83(46): 3918-3920
Roig, P.; Carrasco, R.; Salavert, M.; Nieto, A.; Bernacer, B.; Rodríguez, M.; Navarro, V. 1992: Fluconazole treatment of cryptococcal meningitis associated with HIV infection. Presentation of 4 cases Revista Clinica Espanola 190(3): 125-127
Ong, C.T.; Tsai, J.J.; La, M.L. 1993: Clinical experience with fluconazole monotherapy in cryptococcal meningitis: report of four cases Journal of the Formosan Medical Association 92(Suppl 2): S93-S97
Asawavichienjinda, T.; Sitthi-Amorn, C.; Tanyanont, V. 1999: Serum cyrptococcal antigen: diagnostic value in the diagnosis of AIDS-related cryptococcal meningitis Journal of the Medical Association of Thailand 82(1): 65-71
Kawakami, Y.; Fukunaga, Y.; Hashimoto, K. 1996: Changes of neopterin in cerebrospinal fluid and serum in children with meningitis No to Hattatsu 28(1): 23-29
Kanoh, Y.; Ohara, T.; Akahoshi, T. 2011: Acute Inflammatory Biomarkers in Cerebrospinal Fluid as Indicators of Blood Cerebrospinal Fluid Barrier Damage in Japanese Subjects with Infectious Meningitis Clinical Laboratory 57(1-2): 37-46
Sirkis, S.I. 1982: Serum and cerebrospinal fluid enzyme spectra in meningitis and their differential diagnostic value Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova 82(2): 193-197
Köhler, E.; Klaer, U.; Meyer, F.P.; Walther, H. 1991: Quantitative chloramphenicol detection in serum and cerebrospinal fluid of infants with bacterial meningitis Kinderarztliche Praxis 59(1-2): 38-43
Shanmugasundaram, N.; Thomas, P.A.; Jaypal, V.; Gnanavendhan, S.G.; Subramanian, S. 1988: A study of the serum and cerebrospinal fluid immunoglobulin profile in pyogenic and tuberculous meningitis Indian Journal of Pathology and Microbiology 31(2): 27-34
Greenwood, B.M.; Whittle, H.C. 1974: Nature of the antigen present in the cerebrospinal fluid and serum of patients with group a meningococcal meningitis Clinical and Experimental Immunology 16(3): 413-417
Muchi, H.; Ijima, H.; Karube, T. 1985: The treatment of childhood acute lymphoblastic leukemia based on the pharmacokinetics of methotrexate in serum and cerebrospinal fluid Nihon Ketsueki Gakkai Zasshi: Journal of Japan Haematological Society 48(6): 1397-1408