Acute antenatal hypoxia on different stages of embryogenesis changes the offspring behavior patterns and biogenic amine levels
Graf, A.V.; Maslova, M.V.; Maklakova, A.S.; Sokolova, N.A.; Goncharenko, E.N.; Baĭzhumanov, A.A.; Krushinskaia, I.V.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 91(2): 152-157
2005
ISSN/ISBN: 0869-8139 PMID: 15835538 Document Number: 584808
The effects of acute hypobaric hypoxia on the stages of progestation or beginning of organogenesis on biogenic amines levels in brain stem and cerebral cortex of their mature offspring as well as on their behavior, were investigated. It was shown that acute hypoxia applied in the period of embryonic organogenesis resulted in severe delayed changes in offspring spontaneous behavior and led to marked changes of biogenic amine levels, particularly expressed for dopaminergic system. Females subjected to antenatal hypoxia happened to be more sensitive to its influences than males.