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Biogenic amine study in the spinal cord of experimental cervical myelopathy

Shigetomi, Y.

Nihon Seikeigeka Gakkai Zasshi 54(4): 371-380

1980

ISSN/ISBN: 0021-5325
PMID: 7391630
Document Number: 162457
Concentrations of norepinephrine (NE), dopamine (DA), and serotonin (5HT) within cervical spinal cord specimens were determined using rabbits as the experimental animals. The animals were divided into three groups according to clinical results after cord compression operations which were performed with screws. The first group showed no neurlogical deficit, the second showed symptoms of acute spinal cord injury, and the third showed symptoms of experimental cervical myelopathy. Amines were assayed in three cord segments; at the compression site, rostral, and caudal to the site. DA and 5HT showed no remarkable changes at any site in either group. Mean average was 0.033 microgram/gm +/- 0.009 for DA and 0.54 microgram/gm +/- 0.08 for 5HT. NE showed significant elevation (0.237 microgram/gm +/- 0.013) at the compression site of the experimental group of acute spinal cord injury as compared with controls (0.151 microgram/gm +/- 0.03). The experimental cervical myelopathy group had no significant changes in NE levels at any site. The effects of hypoxia were then examined within each group, using a closed dessicator to achieve an hypoxic state. NE was assayed as before, but the results were same and significant elevation of NE was also observed at the compression site of the experimental animals of acute spinal cord injury with hypoxia.

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Matsumoto, M.; Toyama, Y.; Ishikawa, M.; Chiba, K.; Suzuki, N.; Fujimura, Y. 2000: Increased signal intensity of the spinal cord on magnetic resonance images in cervical compressive myelopathy. Does it predict the outcome of conservative treatment? Spine 25(6): 677-682
Soeda, S. 1988: An experimental study on conductive spinal cord action potentials evoked by direct stimulation of the spinal cord--pathway and source of conductive action potentials in the spinal cord Nihon Seikeigeka Gakkai Zasshi 62(5): 535-549
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Serebrovskaia, I.A.; Zhangelova, M.B.; Baĭmanova, K.M.; Baranova, G.V. 1982: Biogenic amine metabolism in experimental pulmonary edema Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 4: 72-75
Masur, H.; Elger, C.E.; Render, K.; Fahrendorf, G.; Ludolph, A.C. 1988: Function of the long spinal cord pathways in cervical spinal stenosis--an electrophysiologic study Eeg-Emg Zeitschrift für Elektroenzephalographie Elektromyographie und verwandte Gebiete 19(4): 264-266
Karevina, T.G.; Shevchuk, I.M. 1988: Effect of blockaders of biogenic amine receptors on experimental ulcer development Farmakologiia i Toksikologiia 51(4): 56-60
Hirofuji, E.; Tanaka, S. 1989: Effects of thyrotropin-releasing hormone on neurologic recovery and biogenic amine metabolites of cerebrospinal fluid in spinal disorders Nihon Seikeigeka Gakkai Zasshi 63(11): 1306-1315
Sudo, N. 1980: Clinical application of the evoked spinal cord potentials. Part 1. Neurophysiological assessment of the evoked spinal cord potentials in experimental cord trauma - with reference to cord compression and ischemia Nihon Seikeigeka Gakkai Zasshi 54(12): 1631-1647
Veleanu, C. 1975: The cervical locking mechanism. its contribution to the cervical spine stability and to the vertebral artery and spinal cord safety. An anatomical study Morphologie et Embryologie 21(1): 3-7
Rao, S.C.; Fehlings, M.G. 1999: The optimal radiologic method for assessing spinal canal compromise and cord compression in patients with cervical spinal cord injury. Part I: An evidence-based analysis of the published literature Spine 24(6): 598-604
Isu, T.; Iwasaki, Y.; Akino, M.; Abe, H. 1990: Effect of mannitol administration and myelotomy on acute experimental spinal cord injury: investigation by spinal cord evoked potential No Shinkei Geka. Neurological Surgery 18(3): 267-272
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Yanagihara, C.; Nakaji, K.; Nishimura, Y. 2000: A case of HTLV-i associated myelopathy with abnormal patchy MRi lesions in the spinal cord Rinsho Shinkeigaku 40(3): 254-258
Cervello, A.; Morera, J.; López-Trigo, J.; Escudero, J.; Lominchar, J. 1989: Spinal cord involvement by the human immunodeficiency virus. Vacuolar myelopathy Archivos de Neurobiologia 52(Suppl 1): 73-78
Walker, W.C.; Khokhar, M.S. 1992: Silent cardiac ischemia in cervical spinal cord injury: case study Archives of Physical Medicine and Rehabilitation 73(1): 91-94
Dal Pozzo, G.; Taverni, N.; Mascalchi, M.; Siracusa, G.F.; Tanfani, G.; Bartolozzi, C. 1989: Magnetic resonance study of lesions of the cervical spinal cord in multiple sclerosis La Radiologia Medica 78(1-2): 23-29
Laure-Kamionowska, M.; Dambska, M.; Steckiewicz, S.; Golebiowska, D. 1994: Developmental vascular anomalies of the spinal cord as a background for post radiation necrotizing myelopathy Clinical Neuropathology 13(3): 117-119