The role of viral infection in emergence and progression of primary glomerulonephritis and some nephropathies
Varshavskiĭ, V.A.; Golitsina, E.P.; Rybin, P.N.; Fedorov, D.N.
Arkhiv Patologii 66(6): 28-33
2004
ISSN/ISBN: 0004-1955 PMID: 15648164 Document Number: 584186
The results of this study confirm the importance of virus infection in nephropathy onset and progression. Virus-like inclusions were found at electron microscopy in 70 (46 children and 24 adults) of 136 total diagnostic biopsies. In another group of patients (68 adults--50 males and 18 females) with virus-like inclusions in the kidney biopsy studied electron microscopically detected 12 types of viruses observed by PCR in the tissue, present either separately or in various combinations, 2 or 3 simultaneously. The most widespread were Herpes simplex virus, adenovirus and hantovirus. Interrelationship between morphological forms of nephropathies and observed viruses is analyzed. Parvovirus B19 was observed only in FSGS/G and arteryohyalinosis.