Hepatitis B infection and primary glomerulonephritis in children
Naumova, V.I.; Ilamanov, M.; Ivanov, V.G.; Ni, A.N.
Pediatriia 7: 57-62
1991
ISSN/ISBN: 0031-403X PMID: 1754329 Document Number: 386413
Out of 165 children presenting with renal pathology, HBV-infection was detected by RIA in 69.7% of children suffering from glomerulonephritis and in 30.8% of children with pyelonephritis. The infection manifested by the carriage of HBs-antigen and persistent hepatitis. Unlike the control group (without HBv-infection), in patients with HBv-infection, glomerulonephritis was characterized by the development of a prognostically unfavourable mixed form there of in children under 7 years, by rare cases of the onset of a complete remission consequent to immunosuppressive therapy, a decline of the level of serum IgG and the T lymphocyte count, a reduction of the helper/suppressor ratio to 1.21 at the expense of a decrease of the number of helpers, and a higher amount of lymphocytes expressing receptors to IL-2.