Effects of C-terminal fragment of substance P-CP 5-11 on the activity of neurons of the dorsal raphe nucleus
Kryzhanovskiĭ, G.N.; Igon'kina, S.I.; Trubetskaia, V.V.; Oeme, P.; Odariuk, I.
Biulleten' Eksperimental'noi Biologii i Meditsiny 112(12): 578-580
1991
ISSN/ISBN: 0365-9615 PMID: 1723329 Document Number: 386412
The experiments on Wistar rats showed that microinjection of C-terminal fragment of substance P-CP5-11 (1 microgram) into one of the antinociceptive system structure--dorsal raphe nucleus, caused a prolonged (24 hours of observation) analgetic effect by the hot plate test. Neuronal activity of dorsal raphe nucleus simultaneously enhanced. The CP5-11 antinociceptive activity was higher than the CP1-11 one. The conclusion is that CP1-11 and in particular its C-terminal fragment CP5-11 play a role in activation of antinociceptive system.