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Effects of oral squamous cell carcinoma-derived TGF-beta1 on CD26/DPPIV expression in T cells

Uematsu, T.; Tanaka, H.; Yamaoka, M.; Furusawa, K.

Anticancer Research 24(2b): 619-624

2004

ISSN/ISBN: 0250-7005
PMID: 15161003
Document Number: 583449
Background: Enzymatic activity levels of serum CD26/ dipeptidylpeptidase (DPP) IV in oral cancer patients are lower than those in healthy subjects. However; the mechanism for this decrease is not yet fully understood. Materials and Methods: The influence of malignant cell-derived cytokines on cell surface CD26/DPP IV expression in human T cells was analyzed using an oral squamous cell carcinoma (SCC) cell line, KB, and peripheral blood T cells. Results: Tumor growth factor (TGF)-beta1 in KB-conditioned medium (KBCM) down-regulated CD26/DPPIV expression in T cells, which was responsible for the decreased DPPIV activities in the cultured supernatant. Expression p27kip in T cells was maintained in addition to G1 arrest when cultured with KBCM but was abolished by inclusion of anti-TGF-beta1 antibody. Conclusion: SCC-derived TGF-beta1 down-regulates CD26/ DPPIV expression in T cells, resulting in decreased serum CD26/DPPIV activity in oral cancer patients.

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