The immunohistochemical study to comparing PCNA and p53 expression in oral squamous cells carcinoma
Chen, Y.Y.; Wang, Z.; Tang, X.M.
Shanghai Kou Qiang Yi Xue 6(4): 208-212
1997
ISSN/ISBN: 1006-7248 PMID: 15160196 Document Number: 469930
We have studied expression of the PCNA and p53 protein in oral squamous cells carcinoma by ABC immunhistochemical technique,and analyzed the characteristic about clinical pathological parameters and metastasis between them.This result showed PCNA expression were corrected with tumor grading,but not with tumor invasion.There was strong correlation between p53 over expression and tumor invasion and lymph node metastasis.p53 positive tumours have highly lymph node metastasis(60%),but p53 negative tumours have lower(29%).Overexpression of p53 was found to be relatively higher,although not statistically significant in buccal mucosa than in other sites.p53 and PCNA may be an useful indication to the clinician to predict tumour behavior and prognosis.