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Presence of human beta-defensin-2 in oral squamous cell carcinoma

Mizukawa, N.; Sawaki, K.; Yamachika, E.; Fukunaga, J.; Ueno, T.; Takagi, S.; Sugahara, T.

Anticancer Research 20(3b): 2005-2007

2000

ISSN/ISBN: 0250-7005
PMID: 10928142
Document Number: 520202
The purpose of this study was to demonstrate immunohistochemically the localization and distribution of human beta-defensin-2 (HBD-2), a peptide with antimicrobial activity, in oral carcinoma tissues. Tissue samples were embedded in paraffin, and HBD-2 was immunostained by the streptavidin-biotin coupled peroxidase method. Cancer cells in the cornified region of well differentiated squamous cell carcinomas were stained intensely. Stained cancer cells detected by anti- HBD-2 antibody were scattered among the cells of the non-cornified region.

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