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Roles of Wnt-1, beta-catenin and adenomatous polyposis coli in the differentiation and proliferation of oral squamous cell carcinoma

Zhang, W.-m.; Gao, Y.

Zhonghua Kou Qiang Yi Xue Za Zhi 40(6): 491-494

2005

ISSN/ISBN: 1002-0098
PMID: 16329837
Document Number: 592198
To investigate the expressions of Wnt-1, beta-catenin and adenomatous polyposis coli (APC) in oral squamous cell carcinoma (OSCC). Surgical specimens from 66 OSCC patients were examined for Wnt-1, beta-catenin, APC and MIB-1 expressions by immunohistochemical staining. Among all the 37 cases of well differentiated OSCCs, there were 30, 25 and 31 cases of high expressions of Wnt-1, APC and beta-catenin, respectively, 7, 12 and 6 cases of low expressions. Among all the 29 cases of moderate and poor differentiated OSCCs, there were 6, 9 and 11 cases of high expressions of Wnt-1, APC and beta-catenin respectively, 23, 20 and 18 cases of low expressions. Among all the 66 cases of OSCCs, there were 32 cases of high expressions of MIB-1 and 34 cases of low expressions. Expressions of Wnt-1, beta-catenin and APC showed significant difference in different differentiation of OSCC. Wnt-1, beta-catenin and APC expressions were related to the differentiation of OSCC.

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Ammann, R.W.; Deyhle, P.; Sulser, H. 1976: Familial 'minor' adenomatous polyposis coli associated with gastric carcinoma - a hiterto undescribed phenotype of polyposis coli? Scandinavian Journal of Gastroenterology 11(3): 233-240
Zajac, V.; Kovác, M.; Kirchhoff, T.; Stevurková, V.; Tomka, M. 2002: The most frequent APC mutations among Slovak familial adenomatous polyposis patients. Adenomatous polyposis coli Neoplasma 49(6): 356-361
Tataroglu, C.; Karabacak, T.; Apa, D.Düşmez. 2007: Beta-catenin and CD44 expression in keratoacanthoma and squamous cell carcinoma of the skin Tumori 93(3): 284-289
Hargest, R.; Eldin, A.; Williamson, R. 1998: Gene therapy for familial adenomatous polyposis. Prolonged expression of the adenomatous polyposis coli gene after lipofection into mouse colon in vivo Advances in Experimental Medicine and Biology 451: 385-391
Kikuchi-Yanoshita, R.; Konishi, M.; Ito, S.; Seki, M.; Tanaka, K.; Maeda, Y.; Iino, H.; Fukayama, M.; Koike, M.; Mori, T. 1992: Genetic changes of both p53 alleles associated with the conversion from colorectal adenoma to early carcinoma in familial adenomatous polyposis and non-familial adenomatous polyposis patients Cancer Research 52(14): 3965-3971
Liu, B.-Y.; Cao, G.; Dong, Z.; Chen, W.; Xu, J.-K.; Zhang, S.-L.; Weng, Z.-Q. 2016: Knockdown of Grb7 inhibits growth of oral squamous cell carcinoma, cell proliferation and promoted apoptosis through ERK/FOXM1 pathway Shanghai Kou Qiang Yi Xue 25(6): 688-693
Sheng, J.-q.; Li, S.-r.; Yang, X.-y.; Zhang, Y.-h.; Su, H.; Yu, D.-l.; Yan, W.; Geng, H.-g. 2006: Clinical management of adenomatous polyposis in patients with hereditary non-polyposis colorectal cancer and familial adenomatous polyposis Zhonghua Yi Xue Za Zhi 86(8): 526-529
Kamei, J.; Toyofuku, T.; Hori, M. 2003: Negative regulation of p21 by beta-catenin/TCF signaling: a novel mechanism by which cell adhesion molecules regulate cell proliferation Biochemical and Biophysical Research Communications 312(2): 380-387
Mizukawa, N.; Sawaki, K.; Yamachika, E.; Fukunaga, J.; Ueno, T.; Takagi, S.; Sugahara, T. 2000: Presence of human beta-defensin-2 in oral squamous cell carcinoma Anticancer Research 20(3b): 2005-2007
Tsai, C.C.; Chen, C.C.; Lin, C.C.; Chen, C.H.; Lin, T.S.; Shieh, T.Y. 1999: Interleukin-1 beta in oral submucous fibrosis, verrucous hyperplasia and squamous cell carcinoma tissues Kaohsiung Journal of Medical Sciences 15(9): 513-519
Lan, H.A.; Zain, R.B.; Saitoh, M.; Muramatsu, Y.; Shrestha, P.; Mori, M. 1996: Proliferating cell nuclear antigen (PCNA) and p53 in epithelial dysplasia and squamous cell carcinoma of oral mucosa--a marker for poor tumor differentiation, increasing nuclear atypia and invasiveness? Anticancer Research 16(5b): 3059-3065
Zámečník, M.; Bartoš, P.; Kaščák, P. 2015: Shadow cell differentiation in endometrioid carcinomas of the uterus. its frequent occurrence and beta-catenin expression Ceskoslovenska Patologie 51(3): 123-126
Zang, T.; Zhuang, L.; Zhang, Z.; Xin, D.; Guo, Y. 2001: Expression of beta-catenin in renal cell carcinoma Chinese Medical Journal 114(2): 152-154
Mattiuzzo, M.; Biscaro, R.; Scapinello, A.; Ferraccioli, G.F. 2003: Familial adenomatous polyposis coli associated arthritis and vasculitis Clinical and Experimental Rheumatology 21(6): 800
Johnson, J.A.; Talton, D.S.; Poole, G.V. 1993: Adenocarcinoma of a Brooke ileostomy for adenomatous polyposis coli American Journal of Gastroenterology 88(7): 1122-1124
Landauer, S.; Halimi, C.; Caulin, C.; Bergmann, J.F. 1999: Role of suindac in the treatment of familial adenomatous polyposis coli Therapie 54(6): 675-682
Asaumi, J. 1997: Influence of stage classification, tumor differentiation and mode of invasion against clinical and histopathological effects on low dose sequential methotrexate and 5-fluorouracil administration as neo-adjuvant chemotherapy for oral squamous cell carcinoma In Vivo 11(2): 147-151
Grobbelaar, J.J.; Fortuin, R.; Scholtz, C.L.; Zikind, A.; Langenhoven, E.; Wyllie, A.H.; Bubb, V.J.; Kotze, M.J. 2000: Familial adenomatous polyposis coli in South Africa--molecular basis and diagnosis South African Medical Journal 90(7): 715-719
Müller, A.; Hürlimann, R.; Meyenberger, C.; Staub, P.; Kobler, E.; Ammann, R. 1994: Sulindac in familial adenomatous polyposis coli--preliminary findings of a prospective study Schweizerische Medizinische Wochenschrift 124(15): 651-654
Smaali, I.; Bachraoui, K.; Joulek, A.; Selmi, K.; Boujnah, M.R. 2008: Infectious endocarditis secondary to streptococcus bovis revealing adenomatous polyposis coli La Tunisie Medicale 86(7): 723-724