Familial 'minor' adenomatous polyposis coli associated with gastric carcinoma - a hiterto undescribed phenotype of polyposis coli?
Ammann, R.W.; Deyhle, P.; Sulser, H.
Scandinavian Journal of Gastroenterology 11(3): 233-240
1976
ISSN/ISBN: 0036-5521 PMID: 1273501 Document Number: 104177
A clinical study of a family with a high incidence of death from gastric cancer in the 2nd generation was presented. Endoscopic and/or surgical evaluation of the stomach, upper small intestine and colon in 14 mainly asymptomatic members of the 3rd and 4th generations revealed single or multiple (solitary) papillary adenomas in the colon or jejunum in 2 members each of the 2 generations. In addition, single or multiple hyperplastic polyps in the stomach or colon were found in 5 members, 4 of them in association with papillary adenomas. The findings were consistent with minor adenomatous polyposis coli associated with gastric carcinoma. Gastric carcinoma probably represents another phenotype among the vast variety of extra-colonic and extra-alimentary neoplastic changes known to occur in association with familial polyposis coli (FPC). The relationship of hyperplastic polyps to papillary adenoma in the colon and to gastric carcinoma respectively was discussed. Evidence for a genetic relationship between family and a case with probable FPC was presented.