Pharmacokinetics of beta-asarone in rats
Wu, H.-b.; Fang, Y.-q.
Yao Xue Xue Bao 39(10): 836-838
2004
ISSN/ISBN: 0513-4870 PMID: 15700827 Document Number: 582963
To study the pharmacokinetics of beta-asarone in rats. The concentration of beta-asarone in serum and organs were measured by HPLC after i.g. administration, the pharmacokinetics was analyzed with DAS software regarding the organs as independent system. The pharmacokinetics of beta-asarone can be described as first order process of one-compartment model. In the serum, T(1/2), Tpeak and Cmax were 54 min, 12 min and 3.19 mg x L(-1), respectively. The procedure in the organs was similar to that in serum. The absorption, distribution and elimination of beta-asarone are very rapid, and it is easy to pass through blood brain barrier. Brain is an important organ of distributing of beta-asarone.