Expression of the immediate-early gene cFos in brain of the rats exposed to repeated 2 G influence
Fidelina, O.V.; Krasnov, I.B.
Journal of Gravitational Physiology a Journal of the International Society for Gravitational Physiology 11(2): P35-P36
2004
ISSN/ISBN: 1077-9248 PMID: 16231445 Document Number: 580852
Early gene c-Fos expression was studied by means of c-Fos protein immunostaining in brain locus coeruleus (LC) of the rats exposed to primary and repeated hypergravity. One-hour 2 G influence on rats induced in LC cells expression of c-Fos protein, pointing out early gene c-Fos expression and synaptic activation of LC neurons. After repeated 1-hour 2 G, postponed for 35 days after primary 30-day 2 G influence, expression of c-Fos protein in LC neurons was not found. This fact is considered as a sign of memorizing of primary hypergravity influence.