Expression of immediate early gene c-fos in rat brain following increased intracranial pressure
Matsumoto, T.; Masago, A.; Yamada, K.; Iwata, A.; Harada, S.; Mase, M.
Acta Neurochirurgica. Supplement 71: 195-199
1998
ISSN/ISBN: 0065-1419 PMID: 9779182 Document Number: 485391
No attention has been given to an influence of the intracranial pressure (ICP) elevation on the brain at the level of the gene. In the present study, we originally attempted to evaluate the molecular biological changes of the brain, especially the expression of c-fos mRNA as a marker of cellular response, caused by increased ICP. Our results confirm that the neurons and non-neuronal cells are well able to tolerate the stress of increased ICP at the level of the gene, under the condition that cerebral blood flow (CBF) is maintained. A severe increase in ICP, which reduces CBF, enhances the c-fos mRNA expression in a similar fashion as in a forebrain ischemia model, except in the choroid plexus.