Alpha-adducin gene G/W460 polymorphism is associated with intracerebral hemorrhage in Chinese
Dou, X.-f.; Zhang, H.-y.; Huang, X.-h.; Liu, X.-n.; Ju, Z.-y.; Sun, K.; Wang, D.-w.; Liao, Y.-h.; Ma, A.-q.; Zhu, Z.-m.; Zhao, B.-r.; Zhao, J.-z.; Song, Y.; Zhang, L.; Hui, R.-t.
Zhonghua Yi Xue Za Zhi 84(3): 186-188
2004
ISSN/ISBN: 0376-2491 PMID: 15059531 Document Number: 578495
To explore the association between alpha-adducin (ADD1) G/W460 and intracerebral hemorrhage (ICH) in Chinese. Samples of peripheral blood were collected from 456 patients with ICH diagnosed by CT or MRI from 7 clinical centers in China and 454 age, sex, and geographically matched subjects as controls. The ADD1 G/W460 polymorphism was detected by PCR. Information about prior exposure to various potential risk factors was collected by questionnaire survey. The distribution of ADD1gene G460W polymorphisms in the ICH patients and controls were in agreement with the Hardy-Weinberg proportion. The prevalence of 460W allele among ICH cases was 82.2%, higher than that in the controls (76.0%, crude odds ratio, 1.46; 95% CI, 1.05 to 2.05). The ADD1 460W allele was still significantly associated with ICH after adjustment for hypertension and other ICH putative risk factors (adjusted odds ratio, 1.38; 95% CI, 1.01 to 1.88). Alpha-adducin gene G/W 460 polymorphism is significantly associated with the risk of ICH. This association does not appear to be mediated by established ICH risk factors, specifically hypertension status.