Association of peripheral and central blood pressure with the alpha-adducin Gly460Trp polymorphism in a Chinese population
Guo, H-feng.; Li, Y.; Wang, G-liang.; Lu, Y-gang.; Zhou, H-fa.; Gao, P-jin.; Zhu, D-liang.; Wang, J-guang.
Zhonghua Xin Xue Guan Bing Za Zhi 33(7): 608-612
2005
ISSN/ISBN: 0253-3758 PMID: 16080807 Document Number: 588879
Objective To investigate the association of peripheral and central blood pressure with the alpha-adducin Gly460Trp polymorphism in Chinese. Methods We randomly selected 6 villages from JingNing County, ZheJiang Province. We invited nuclear families to take part in our study. We measured each participant's blood pressure at the non-dominant arm by means of a standard mercury sphygmomanometer at subjects' homes. Five consecutive readings were averaged for analysis. Central blood pressures were obtained by use of SphygmoCor pulse wave analysis system. The observers administered a standardized questionnaire to collect information on smoking habits, alcohol consumption and use of antihypertensive drugs. Venous blood was sampled and the adducin genotype was determined by restrictive fragment length polymorphism ( RFLP). Results Four hundred and forty-two subjects included 230 (52.0%) women, and 116 (26.2%) hypertensive patients, of whom 49 (11.1%) took antihypertensive drugs. The frequencies of alpha-adducin GlyGly, GlyTrp and TrpTrp genotypes were 21.3%, 54.5% and 24.2%, respectively. There was no association between the alpha-adducin Gly460Trp polymorphism and peripheral systolic and diastolic blood pressure and pulse pressure. However, both before and after adjustment for sex, age, age(2), body-mass index, current smoking, alcohol intake, and antihypertensive treatment, the alpha-adducin polymorphism was significantly (P<0.02) associated with central systolic blood pressure and central pulse pressure. After adjustment, central systolic blood pressure (+/- SE) averaged 122.5 +/- 3.5, 114.1 +/- 1.5 and 109.1 +/- 1.8 mm Hg (P=0.01) in the GlyGly, GlyTrP and TrpTrp subjects, respectively. The corresponding values for central pulse pressure were 39.4 +/- 1.3, 36.4 +/- 1.0 and 32.9 +/- 0.9 mm Hg (P=0.002), respectively. Conclusions In the JingNing population, the adducin 460Trp allele was associated with lower levels of central systolic pressure and pulse pressure.