Angiotensin I-converting enzyme gene polymorphism in Chinese patients with obstructive sleep apnea syndrome
Xiao, Y.; Huang, X.; Qiu, C.; Zhu, X.; Liu, Y.
Chinese Medical Journal 112(8): 701-704
1999
ISSN/ISBN: 0366-6999 PMID: 11601275 Document Number: 509390
To investigate the relationship of an insertion/deletion (I/D) polymorphism of the angiotension-converting enzyme (ACE) gene to obstructive sleep apnea syndrome (OSAS) patients and the control subjects. Genomic DNA was extracted from blood samples and amplified by polymerase chain reaction (PCR). PCR primers flanked the polymorphic region in intro 16 of the ACE gene. OSAS patients had significantly higher frequencies of I/I genotype and insertion allele of the ACE gene as compared with the control subjects in Chinese population. The OSAS patients with I/I genotype had significantly longer apnea time, lower minimum SaO2 and greater AHI than the OSAS patients with I/D genotype. These results indicate that the I/I genotype and I allele are a risk factor for OSAS in Chinese.