Association analysis of polymorphism in angiotensin-converting enzyme gene in ischemic stroke
Moliaka, I.K.; Petruk, S.V.; Kir'ianov, S.A.; Dzhibladze, A.N.; Chechetkin, A.O.; Shcherbatykh, T.V.; Rogaev, E.N.
Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova 98(6): 35-37
1998
ISSN/ISBN: 1997-7298 PMID: 9677696 Document Number: 485614
Family and twins study demonstrated that genetic factors may be involved in stroke. Previously, insertion/deletion (I/D) Alu-polymorphism in the angiotensin-converting enzyme (ACE) gene has been suggested as a risk factor for some cardiovascular diseases. There fore, cardiovascular factors are well-known risk factors for ischemic stroke. We selected patients with ischemic stroke and with no evidence for arterial hypertension and carried out ACE polymorphism analysis. Association study of I/D polymorphism in group of these patients (52 individuals) and 80 control persons from the same population of Russian descent demonstrated no evidence for statistically significant differences in frequencies of I/D alleles or II/DD/ID genotypes between these groups. Thus, it suggests that ACE I/D polymorphism alone is not risk factor for stroke in non-hypertension patients. We cannot, however, exclude possible interaction between ACE-D/D genotype and sex.