Activation of ERK1/2 and Elk1 in A549 cells induced by crocidolite
Wang, X.; Wu, Y.; Li, Z.; Samet, J.M.; Ghio, A.J.
Wei Sheng Yan Jiu 33(4): 398-399
2004
ISSN/ISBN: 1000-8020 PMID: 15461256 Document Number: 575280
To investigate the role of extracellular signal-regulated kinase (ERK) 1/2 and Elk1 in pulmonary disease induced by crocidolite asbestos fiber. Western blotting and Immunoprecipitation were used to detect the expression of phosphorylated ERK1/2 and Elk1 in human bronchial airway A549 cell line stimulated by crocidolite. The expression of phosphorylated ERK1/2 and Elk1 were striking higher than those of the control, the differences were significant (P < 0.05). Phosphorylated ERK1/2 and Elk1 probably involved in the process of the diseases induced by crocidolite.