Altered constitutive and activation-induced expression of CD95 by B- and T-cells in B-cell chronic lymphocytic leukemia
De Fanis, U.; Dalla Mora, L.; Romano, C.; Sellitto, A.; Tirelli, A.; Lucivero, G.
Haematologica 87(3): 325-327
2002
ISSN/ISBN: 0390-6078 PMID: 11869948 Document Number: 542613
Expression of CD95, a molecule involved in activation-induced cell death (AICD), might contribute to explain accumulation of leukemic B-cells and functional impairment of T-cells in B-cell chronic lymphocytic leukemia (B-CLL). There-fore, we compared constitutive and activation-induced expression of CD95 and CD69 by B- and T-cells in CLL patients and in healthy donors.
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