The influence of lectins on the aggregation of neutrophils and erythrocytes in healthy humans
Kirichuk, V.F.; Voskoboĭ, I.V.
Tsitologiia 46(2): 151-154
2004
ISSN/ISBN: 0041-3771 PMID: 15174353 Document Number: 573799
The influence of some plant lectins on the aggregation of neutrophils and erythrocytes in healthy humans was studied, and the state of carbohydrate determinants of glycoprotein receptors of these cells was characterized. These carbohydrate determinants, containing D-mannose, N-acetyl-D-glucosamin, and bD-galactose, provide neutrophil aggregation in healthy persons. The surface receptors of erythrocytes have remains of bD-galactose, several N-acetyl-D-glucosamin, N-acetyl-neyranimic acid, N-acetyl-D-galactosamin, and L-fucose. Thus, in neutrophils and erythrocytes of healthy persons there is a definite composition of carbohydrate determinants of glycoproteins. Changes in these carbohydrate determinants are able to increase cells aggregation and, consequently, to disturb rheological property of the blood, and to impair processes of microcirculation and thrombose stimulation.