The possibilities for application of the canine hookworm vaccine technology to the prevention and control of hookworm infection and disease in man
Miller, T.A.
Nuclear techniques in helminthology research: 61-68
1975
Document Number: 571296
The licensing and commercial introduction of the sterile, irradiated, canine hookworm vaccine in the USA represents a major advance in technology for the prophylaxis against helminth diseases. The industrial technology of this vaccine has been shown experimentally to be directly applicable to certain essential steps in the development of a potential vaccine for the control of hookworm infection of man. Although the occurrence and significance of immunity in the man-hookworm system is still largely conjectural and is based on circumstantial evidence, the balance of evidence indicates that an effective acquired resistance probably operates in this system. This is the most important residual deficiency in our knowledge of this host-parasite relationship. The aesthetic and economic considerations involved in the development and use of a human hookworm vaccine must also represent major relevant considerations. [AS].