Comparative modelling of tetramanganese cluster of Chaetosphaeridium globosum
Rath, L.S.; Raval, M.K.
Indian Journal of Biochemistry and Biophysics 41(5): 258-262
2004
ISSN/ISBN: 0301-1208 PMID: 22900284 Document Number: 569216
The DI protein of photosystem II (PS II) complex of a microalga Chaetosphaeridium globosum has been theoretically modelled from its sequence using comparative modeling with known backbone structure of DI protein from bacterium Thermosynechococcus vulcanus as template. The model is built with missing loops and all side chains, which are not resolved in the structure of the template. The structure of the tetramanganese cluster (TMC) and the ligand forming side chains have been subjected to modeling studies in order to gather more information useful to understanding of the water splitting reactions. Earlier models of TMC have been scrutinized and an insight into the manganese coordination sphere has been provided.