Neuroprotective properties of pyroglutamic acid in combination with pyrrolidone
Lun'shina, E.V.; Gan'shina, T.S.; Makarova, L.M.; Pogorelyĭ, V.E.; Mirzoian, R.S.
Eksperimental'naia i Klinicheskaia Farmakologiia 66(1): 20-22
2003
ISSN/ISBN: 0869-2092 PMID: 12683075 Document Number: 565089
A new drug composition containing pyroglutamic acid and pyrrolidone produces a significant effect on the cerebral circulation in rats with global recurrent brain ischemia and in a model ischemic state under high radial gravitational overload. In the former case, the new drug increases the blood circulation in rats with the global ischemic damage to a greater extent than in the intact control group. Pretreatment with the pyroglutamic acid--pyrrolidone composition produced a 2-2.5-fold increase in the survival of rats in the ischemic state caused by the radial gravitational overload. The data obtained show evidence of a substantial neuroprotector action of the new drug composition.