Neuroprotective effect of N-acylethanolamines in chronic morphine dependence. II. Effect on the rat brain fatty acid composition
Hula, N.M.; Marhitych, V.M.; Klimashevs'kyĭ, V.M.; Horid'ko, T.M.; Artamonov, M.V.; Zhukov, O.D.
Ukrains'kyi Biokhimichnyi Zhurnal 77(2): 112-117
2005
ISSN/ISBN: 0372-3909 PMID: 16335242 Document Number: 587956
The effect of N-acylethanolamines mixture (NAE) with saturated and unsaturated acyl chains on the fatty acid composition of the rat brain under chronic morphine dependence was investigated. Long-term administration of NAE reduced morphine-induced decrease of mono- and polyunsaturated fatty acids in the rat brain crude lipid extract. Furthermore, NAE restored the acyl chain spectrum, especially the content of docosahexaenoic acid in essential phospholipids--phosphatidylcholine and phosphatidylethanolamine. Pharmacological activity of NAE depended on a dose.