Effects of steroids on the in vitro forward migration of human spermatozoa
Cheng, C.Y.; Boettcher, B.
Contraception 24(2): 183-194
1981
ISSN/ISBN: 0010-7824 PMID: 7297069 DOI: 10.1016/0010-7824(81)90091-3Document Number: 562650
The effects of 14 steroids at concentrations between 0.1 and 10 .mu.g/ml on human spermatozoal forward migration in vitro were tested. Estradiol-17.beta. at a concentration of 0.1 .mu.g/ml significantly activated spermatozoal forward migration in ejaculated human semen. The effect of estradiol-17.beta. at concentrations of 2 and 10 .mu.g/ml on ejaculated human sperm motility was not significantly different from the control where no steroid was added. Progesterone, testosterone, estriol, estrone, estradiol-17.beta. and ethinyl estradiol significantly inhibited human spermatozoal forward migration at concentrations of 10 .mu.g/ml. Chlormadinone acetate and medroxyprogesterone acetate at concentrations of 2 and 10 .mu.g/ml significantly inhibited human spermatozoal forward migration, while norethynodrel, ethynodiol diacetate, norgestrel and lynestrenol significantly inhibited human spermatozoal forward migration at concentrations between 0.1 and 10 .mu.g/ml. Norethindrone had no demonstrable effect on human spermatozoal forward migration at the above concentrations.
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